Conversion of major ginsenoside Rb1 to ginsenoside F2 by Caulobacter leidyia

Ginsenoside Rb1 is the most predominant ginsenoside in Panax species (ginseng) and the hydrolysis of this ginsenoside produces pharmaceutically active compounds. Caulobacter leidyia GP45, one of the isolates having strong beta-glucosidase-producing activity, converted ginsenoside Rb(1) to the active...

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Published inBiotechnology letters Vol. 28; no. 14; pp. 1121 - 1127
Main Authors CHENG, Le-Qin, MYUNG KYUM KIM, LEE, Jun-Won, LEE, Youn-Jin, YANG, Deok-Chun
Format Journal Article
LanguageEnglish
Published Dordrecht Springer 01.07.2006
Springer Nature B.V
Subjects
Biological and medical sciences
Biotechnology
Biotransformation
Caulobacter - classification
Caulobacter - metabolism
Fundamental and applied biological sciences. Psychology
Ginsenosides - chemistry
Ginsenosides - metabolism
Metabolites
Species Specificity
Caulobacterales
Ginseng biotransformations
Biotransformation
Ginsenoside F2
Bacteria
Caulobacter leidyia
Caulobacteraceae
Ginsenoside Rb1
Caulobacter
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Summary:Ginsenoside Rb1 is the most predominant ginsenoside in Panax species (ginseng) and the hydrolysis of this ginsenoside produces pharmaceutically active compounds. Caulobacter leidyia GP45, one of the isolates having strong beta-glucosidase-producing activity, converted ginsenoside Rb(1) to the active metabolites by 91%. The structures of the resultant metabolites were identified by NMR. Ginsenoside Rb1 had been consecutively converted to ginsenoside Rd (1), F2(2) and compound K (3) via the hydrolyses of 20-C beta-(1-->6)-glucoside, 3-C beta-(1-->2)-glucoside, and 3-C beta-glucose of ginsenoside Rb1.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-006-9059-x