Choroidal melanocytes — a model for studying the aging process in nonreplicative differentiated cells

Choroidal melanocytes differentiate and cease to divide early in postnatal life. They have characteristic organelles, the melanosomes, which are formed from tyrosine in a reaction catalyzed by tyrosinase. As animals become old, enzyme activity declines and the melanosomes show changes that are quant...

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Bibliographic Details
Published inMechanisms of ageing and development Vol. 11; no. 4; pp. 227 - 235
Main Authors Hu, Funan, Mah, Kunie
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.11.1979
Subjects
Aging
Animals
Choroid - cytology
Choroid - ultrastructure
Haplorhini
Lipofuscin - analysis
Macaca mulatta
Melanocytes - ultrastructure
Microscopy, Fluorescence
Pigment Epithelium of Eye - ultrastructure
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Summary:Choroidal melanocytes differentiate and cease to divide early in postnatal life. They have characteristic organelles, the melanosomes, which are formed from tyrosine in a reaction catalyzed by tyrosinase. As animals become old, enzyme activity declines and the melanosomes show changes that are quantitatively and qualitatively correlated to the animal's increasing age.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0047-6374
1872-6216
DOI:10.1016/0047-6374(79)90002-2