In vivo metabolism of esterified cholesterol and apoproteins in rabbit plasma low density lipoproteins

Preparations of rabbit low density lipoproteins (LDL) labelled with 3H in the esterified and free cholesterol moieties and with 125I in the apoprotein moiety were injected intravenously into other rabbits. A substantial proportion of the esterified [ 3H]cholesterol removed from LDL during the first...

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Published inAtherosclerosis Vol. 34; no. 4; pp. 451 - 455
Main Authors Ha, Y.C., Calvert, G.D., Barter, P.J.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.12.1979
Subjects
Animals
Apolipoproteins - blood
Apoprotein B
Cholesterol Esters - blood
Esterified cholesterol
Kinetics
Lipoproteins, HDL - blood
Lipoproteins, LDL - blood
Lipoproteins, VLDL - blood
Low density lipoproteins
Male
Rabbits
HDL
LDL
Low density lipoproteins
VLDL
WP
TLC
Apoprotein B
EDTA
TMU
Esterified cholesterol
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Summary:Preparations of rabbit low density lipoproteins (LDL) labelled with 3H in the esterified and free cholesterol moieties and with 125I in the apoprotein moiety were injected intravenously into other rabbits. A substantial proportion of the esterified [ 3H]cholesterol removed from LDL during the first 30 min was recovered in the high density lipoprotein (HDL) fraction, while no such transfer of labelled apoprotein was observed. There was a clear cut differential in the decay of the different LDL components, slowest for the apoprotein, intermediate for esterified cholesterol and fastest for free cholesterol.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-9150
1879-1484
DOI:10.1016/0021-9150(79)90069-8