Pulmonary haemorrhage in disseminated cardiac haemangiosarcoma

A male forestry worker presented with chest pain followed by severe continuing haemoptysis and an extensive bilateral nodular pulmonary infiltrate. A needle biopsy of lung demonstrated micronodular deposits of malignant tissue. The patient died from respiratory failure. Necropsy showed a disseminate...

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Bibliographic Details
Published inBritish journal of diseases of the chest Vol. 71; no. 2; pp. 127 - 131
Main Authors Edwards, R.L., Chalk, S.M., McEvoy, J.D.S., Donald, K.J.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 1977
Subjects
Adult
Heart Neoplasms - complications
Hemangiosarcoma - complications
Hemorrhage - etiology
Humans
Lung Diseases - etiology
Lung Neoplasms - ultrastructure
Male
Neoplasm Metastasis
Pulmonary Alveoli - ultrastructure
Respiratory Insufficiency - etiology
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Summary:A male forestry worker presented with chest pain followed by severe continuing haemoptysis and an extensive bilateral nodular pulmonary infiltrate. A needle biopsy of lung demonstrated micronodular deposits of malignant tissue. The patient died from respiratory failure. Necropsy showed a disseminated haemangiosarcoma arising in the right atrium. Haemoglobin and serum iron levels were normal. Electron microscopy of the lung biopsy showed a close relationship between tumour cells and basement membrane and suggested that haemorrhage occurred directly from the tumour nodules. The ultrastructure of alveoli adjacent to tumour deposits was normal. This case provides further indirect evidence that the clinical and histological features of idiopathic pulmonary haemosiderosis cannot be explained by the mere occurrence of alveolar haemorrhage.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0007-0971
1878-2426
DOI:10.1016/0007-0971(77)90094-8