Readiness in preventing filovirus epidemics by use of the marketed vaccines against Zaire Ebola virus disease as prototypes

[...]evidence of the safety of the two vaccine regimens holds promise for the safe insertion of non-Zaire Ebola virus filovirus antigens into the vectors. [...]immunisation of health professionals and at-risk populations should be implemented, preferably with the Ad26.ZEBOV and MVA-BN-Filo vaccine....

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Published inThe Lancet infectious diseases Vol. 24; no. 7; pp. 671 - 673
Main Authors Agnandji, Selidji T, Essone, Paulin N, Medaglini, Donata, Massinga Loembe, Marguerite
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.07.2024
Elsevier Limited
Subjects
Antigens
Disease
Ebola Vaccines - administration & dosage
Ebola Vaccines - immunology
Ebola virus
Ebolavirus
Ebolavirus - immunology
Epidemics
Epidemics - prevention & control
Fever
Hemorrhagic Fever, Ebola - epidemiology
Hemorrhagic Fever, Ebola - prevention & control
Humans
Immunization
Medical personnel
Vaccines
Vectors (Biology)
Viral diseases
Viruses
Zaire
Sudan
Africa
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Summary:[...]evidence of the safety of the two vaccine regimens holds promise for the safe insertion of non-Zaire Ebola virus filovirus antigens into the vectors. [...]immunisation of health professionals and at-risk populations should be implemented, preferably with the Ad26.ZEBOV and MVA-BN-Filo vaccine. [...]immunisation programmes should be paralleled with research into the titres and persistence of anti-Sudan Ebola virus and anti-Marburg virus antibodies induced by the Ad26.ZEBOV and MVA-BN-Filo vaccine regimen and by the heterologous prime–boost immunisation with rVSVΔG-ZEBOV-GP and Ad26.ZEBOV and MVA-BN-Filo, or vice versa.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(24)00297-4