Changes of CD3+CD56+ γδ T cell number and apoptosis during hospital admission are related to mortality in septic patients
Immunoparalysis and apoptosis of T cells are serious problems for the evolution of septic patients. We aimed to relate changes in the number of αβ and γδ T cells during hospital stay to the poor evolution of sepsis. In this prospective study, we recruited a total of 92 septic patients from the Emerg...
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Published in | Clinical immunology (Orlando, Fla.) Vol. 236; p. 108956 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.03.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Immunoparalysis and apoptosis of T cells are serious problems for the evolution of septic patients. We aimed to relate changes in the number of αβ and γδ T cells during hospital stay to the poor evolution of sepsis. In this prospective study, we recruited a total of 92 septic patients from the Emergency and Intensive Care Departments of two Hospitals, according to the latest criteria for the definition and management of sepsis. According to the severity of the septic process, there was a progressive decrease in T cells, being much more intense in γδ T cells. This decrease recovered in surviving patients, but CD3+CD56+ γδ T cells continued to decreased during hospital stay in non-surviving patients. Apoptosis increased in sepsis. Cell death of CD3+CD56+ γδ T cells progressively increased according to the severity of sepsis, especially in non-surviving patients.
•Decreased numbers and increased apoptosis of αβ and γδ T cells are related to the severity and mortality of sepsis.•This decrease is highly significant in CD3+CD56+ γδ T cells and is recovered in surviving septic patients.•Apoptosis of CD3+CD56+ γδ T cells is increased in non-surviving septic patients•CD3+CD56+ γδ T cells and their apoptosis have a great influence on the prognosis of sepsis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1521-6616 1521-7035 |
DOI: | 10.1016/j.clim.2022.108956 |