Diagnosis of Mesothelioma

Mesothelioma is a rare neoplasm that arises from mesothelial cells lining body cavities including the pleura, pericardium, peritoneum, and tunica vaginalis. Most malignant mesotheliomas occur in the chest and are frequently associated with a history of asbestos exposure. The diagnosis of malignant m...

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Bibliographic Details
Published inSurgical pathology clinics Vol. 13; no. 1; p. 73
Main Authors Fels Elliott, Daffolyn Rachael, Jones, Kirk D
Format Journal Article
LanguageEnglish
Published United States 01.03.2020
Subjects
Pleural effusion
Mesothelioma
Sarcomatoid
Reactive mesothelial proliferation
Epithelioid
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Summary:Mesothelioma is a rare neoplasm that arises from mesothelial cells lining body cavities including the pleura, pericardium, peritoneum, and tunica vaginalis. Most malignant mesotheliomas occur in the chest and are frequently associated with a history of asbestos exposure. The diagnosis of malignant mesothelioma is challenging and fraught with pitfalls, particularly in small biopsies. This article highlights what the pathologist needs to know regarding the clinical and radiographic presentation of mesothelioma, histologic features including subtypes and variants, and recent advances in immunohistochemical markers and molecular testing.
ISSN:1875-9157
DOI:10.1016/j.path.2019.10.001