Rapid synthesis and purification of carbon-11 labelled DOPA: a potential agent for brain studies

A rapid methods for preparation and purification of β-(3,4-dihydroxyphenyl)- D,L-α-alanine-1- 11C ( 11C-DOPA), using 11CO 2 as the radioactive precursor is described. Carboxylation of an α-lithioisocyanide, containing protected hydroxylic groups, was followed by a three-step hydrollsis of the interm...

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Published inThe International journal of applied radiation and isotopes Vol. 28; no. 12; pp. 955 - 958
Main Authors Reiffers, S., Molen, H.D.Beerling-van der, Vaalburg, W., Ten Hoeve, W., Paans, A.M.J., Korf, J., Woldring, M.G., Wynberg, H.
Format Journal Article
LanguageEnglish
Published United States Elsevier B.V 01.12.1977
Subjects
Animals
Brain - diagnostic imaging
Carbidopa - pharmacology
Carbon Radioisotopes
Dihydroxyphenylalanine - chemical synthesis
Dihydroxyphenylalanine - pharmacology
Male
Radionuclide Imaging
Rats
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Summary:A rapid methods for preparation and purification of β-(3,4-dihydroxyphenyl)- D,L-α-alanine-1- 11C ( 11C-DOPA), using 11CO 2 as the radioactive precursor is described. Carboxylation of an α-lithioisocyanide, containing protected hydroxylic groups, was followed by a three-step hydrollsis of the intermediate α-isocyano carboxylic acid. Preliminary experiments in rats indicate that the compound is preferentially decarboxylated in brain areas rich in dopamine containing neurons.
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ISSN:0020-708X
DOI:10.1016/0020-708X(77)90060-6