A Drosophila computational brain model reveals sensorimotor processing

• Published in: Nature (London) Vol. 634; no. 8032; pp. 210 - 219
• Main Authors: Shiu, Philip K., Sterne, Gabriella R., Spiller, Nico, Franconville, Romain, Sandoval, Andrea, Zhou, Joie, Simha, Neha, Kang, Chan Hyuk, Yu, Seongbong, Kim, Jinseop S., Dorkenwald, Sven, Matsliah, Arie, Schlegel, Philipp, Yu, Szi-chieh, McKellar, Claire E., Sterling, Amy, Costa, Marta, Eichler, Katharina, Bates, Alexander Shakeel, Eckstein, Nils, Funke, Jan, Jefferis, Gregory S. X. E., Murthy, Mala, Bidaye, Salil S., Hampel, Stefanie, Seeds, Andrew M., Scott, Kristin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.10.2024; Nature Publishing Group
• Subjects: 14/19; 14/28; 14/69; 631/378/116/1925; 631/378/2629/1409; 64/24; Activation analysis; Animals; Behavior; Brain; Brain - cytology; Brain - physiology; Circuits; Computational neuroscience; Computer Simulation; Connectome; Drosophila; Drosophila melanogaster - physiology; Feeding behavior; Feeding Behavior - physiology; Female; Fruit flies; Grooming; Grooming - physiology; Gustatory system; Humanities and Social Sciences; Hypotheses; Information processing; Insects; Male; Microscopy; Models, Neurological; Motor Neurons - physiology; multidisciplinary; Neural networks; Neurogenesis; Neurons; Neurotransmitters; Optogenetics; Predictions; Science; Science (multidisciplinary); Sensorimotor system; Sensory integration; Sensory neurons; Sugar; Synapses; Synapses - physiology; Taste; Taste - physiology
• ISSN: 0028-0836; 1476-4687; 1476-4687
• DOI: 10.1038/s41586-024-07763-9

The recent assembly of the adult Drosophila melanogaster central brain connectome, containing more than 125,000 neurons and 50 million synaptic connections, provides a template for examining sensory processing throughout the brain 1 , 2 . Here we create a leaky integrate-and-fire computational model of the entire Drosophila brain, on the basis of neural connectivity and neurotransmitter identity 3 , to study circuit properties of feeding and grooming behaviours. We show that activation of sugar-sensing or water-sensing gustatory neurons in the computational model accurately predicts neurons that respond to tastes and are required for feeding initiation 4 . In addition, using the model to activate neurons in the feeding region of the Drosophila brain predicts those that elicit motor neuron firing 5 —a testable hypothesis that we validate by optogenetic activation and behavioural studies. Activating different classes of gustatory neurons in the model makes accurate predictions of how several taste modalities interact, providing circuit-level insight into aversive and appetitive taste processing. Additionally, we applied this model to mechanosensory circuits and found that computational activation of mechanosensory neurons predicts activation of a small set of neurons comprising the antennal grooming circuit, and accurately describes the circuit response upon activation of different mechanosensory subtypes 6 – 10 . Our results demonstrate that modelling brain circuits using only synapse-level connectivity and predicted neurotransmitter identity generates experimentally testable hypotheses and can describe complete sensorimotor transformations. We create a computational model of the adult Drosophila brain that accurately describes circuit responses upon activation of different gustatory and mechanosensory subtypes and generates experimentally testable hypotheses to describe complete sensorimotor transformations.