The results of single-event multilevel orthopedic surgeries and the early rehabilitation used in complex with botulinum toxin treatment in patients with spastic forms of cerebral palsy

• Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 115; no. 4; p. 41
• Main Authors: Popkov, D A, Zmanovskaya, V A, Gubina, E B, Leonchuk, S S, Butorina, M N, Pavlova, O L
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2015
• Subjects: Adolescent; Botulinum Toxins - administration & dosage; Botulinum Toxins - therapeutic use; Cerebral Palsy - drug therapy; Cerebral Palsy - rehabilitation; Cerebral Palsy - surgery; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Male; Motor Activity; Muscle Spasticity - drug therapy; Muscle Spasticity - rehabilitation; Muscle Spasticity - surgery; Orthopedic Procedures; Treatment Outcome; Walking
• ISSN: 1997-7298
• DOI: 10.17116/jnevro20151154141-48

To evaluate motor possibilities of patients with children spastic palsy (CSP) one year after single-event multilevel orthopedic low extremity surgeries in combination with early rehabilitation treatment including botulinum toxin treatment. Authors studied the results of operative orthopedic treatment in 55 patients with CSP, aged from 5 to 17 years (mean 11.9 ± 2.5 years), who underwent multilevel surgeries with early functional rehabilitation using 1.5 treatment courses with 6-8 week treatment-free periods during 9-12 months in combination with a single injection of disport in the post-operative period. We performed 74 surgeries 140 episodes of botulinum toxin treatment using average doses of Botulinum toxin 10 U per kg of body mass injected into low extremity muscles. In the post-operative period, authors recorded a significant reduction in pain syndrome, assessed with a pain intensity scale, from 8.6 ± 1.2 to 4.3 ± 1.1 scores (p < 0.001). An analysis of gait demonstrated an improvement of gait patterns in all patients able to move independently. An increase in motor abilities, measured with the Gillette Functional Assessment Questionnaire, by 1 level was identified in 28 (50.9%) patients, by 2 levels in 2 (3.6%) patients, no changes were observed in 25 (45.5%) patients. Single-event multilevel orthopedic surgeries in children with CSP reduce a number of repeated surgeries. The effective control over pain syndrome in patients with CSP using multilevel botulinum toxin treatment in the post-operative period promotes the functional rehabilitation, increases rates of loading during training sessions and the motivation of CSP patients to restore the lost activity.