Spheroids as 3D Cell Models for Testing of Drugs

Cell lines are an important tool for scientific research and clinical and pharmaceutical applications. Cells are isolated from animal tissues and can be expanded in culture to study cell biology and disease. The isolated cells can be used to produce antibodies, proteins, and vaccines. Immortalized c...

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Bibliographic Details
Published inEUROPEAN PHARMACEUTICAL JOURNAL Vol. 70; no. 1; pp. 37 - 43
Main Authors Nováková, E., Mikušová, V., Šupolíková, M.
Format Journal Article
LanguageEnglish
Published Sciendo 01.12.2023
Subjects
2D cell cultures
3D cell cultures
liquid overlay technique
spheroids
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Summary:Cell lines are an important tool for scientific research and clinical and pharmaceutical applications. Cells are isolated from animal tissues and can be expanded in culture to study cell biology and disease. The isolated cells can be used to produce antibodies, proteins, and vaccines. Immortalized cell lines can grow in vitro and are commonly used as models for complex biology. The most frequently used type of cell culture for scientific research and clinical and pharmaceutical applications is the two-dimensional (2D) model, but recently, the popularity of the three-dimensional (3D) cultivation method is growing.
ISSN:2453-6725
2453-6725
DOI:10.2478/afpuc-2023-0008