Fabrication of Indomethacin-Loaded Polyvinyl Alcohol Filaments through Hot-Melt Extrusion

The main objective of this study was to prepare the drug-loaded filament by hot-melt extrusion technique. Indomethacin (IND) was used as a model drug and polyvinyl alcohol (PVA) was used to produce the filament. The IND-PVA filament had clear yellow color and rough surface. Drug loading in the filam...

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Bibliographic Details
Published inKey engineering materials Vol. 859; pp. 247 - 251
Main Authors Thanawuth, Kasitpong, Sriamornsak, Pornsak
Format Journal Article
LanguageEnglish
Published Zurich Trans Tech Publications Ltd 01.08.2020
Subjects
Differential scanning calorimetry
Dosage
Drug dosages
Extrusion
Filaments
Polyvinyl alcohol
Thermogravimetric analysis
Three dimensional printing
X ray powder diffraction
Polyvinyl Alcohol
Indomethacin
Hot-Melt Extrusion
Drug-Loaded Filament
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Summary:The main objective of this study was to prepare the drug-loaded filament by hot-melt extrusion technique. Indomethacin (IND) was used as a model drug and polyvinyl alcohol (PVA) was used to produce the filament. The IND-PVA filament had clear yellow color and rough surface. Drug loading in the filament that was determined from three segments of the filament was similar, indicating that IND was homogeneously distributed in the filament.This finding was confirmed by differential scanning calorimetry and powder X-ray diffraction. In addition, thermogravimetric analysis data suggested that the drug and polymer were not degraded at temperature used in extrusion process. The filament could be further developed as dosage form or applied as starting material for 3D-printed dosage forms.
Bibliography:Selected, peer-reviewed papers from the 3rd International conference and exhibition on Pharmaceutical Sciences and Technology (PST 2020), May 19-20, 2020, Bangkok , Thailand
ISSN:1013-9826
1662-9795
1662-9795
DOI:10.4028/www.scientific.net/KEM.859.247