The Effects of LSD-25 on Alpha Blocking and Conditioning in Epileptic Patients Before and After Temporal Lobectomy

• Published in: Cortex Vol. 1; no. 4; pp. 485 - 492
• Main Author: Serafetinides, E.A.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.06.1965
• ISSN: 0010-9452; 1973-8102
• DOI: 10.1016/S0010-9452(65)80007-7

Studies of alpha conditioning by auditory and tactile stimuli were carried out in two matched groups of intractable epileptic patients who were eventually submitted to an anterior temporal lobectomy on the right (11 cases) or left side (9 cases). The conditioning studies were performed 30–60 min. after the patients had taken 1 μg/kg of LSD-25 orally, and also on a separate day without the drug. The procedure was repeated one month after operation. The conditioning of the alpha was not found to differ significantly under LSD-25, either before or after operation. In the few instances where changes were observed, they were variable and of either direction, i.e. leading to greater or lesser conditioning, according to the case. The need for a more quantitative approach was stressed.