The use of alteplase for restoring patency to occluded central venous access devices in infants and children

A 21-month retrospective review was completed at the Lucile Packard Children's Hospital to assess the experience of 22 infants and children who received alteplase for the clearance of occluded central venous access devices. After the first dose, 86% (n = 19) of the catheters cleared. Two additi...

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Bibliographic Details
Published inJournal of infusion nursing Vol. 27; no. 3; p. 171
Main Authors Fisher, Amy A, Deffenbaugh, Claudia, Poole, Robert L, Garcia, Manuel, Kerner, Jr, John A
Format Journal Article
LanguageEnglish
Published United States 01.05.2004
Subjects
Adolescent
Adult
Catheterization, Central Venous - nursing
Child
Child, Preschool
Female
Fibrinolytic Agents - therapeutic use
Humans
Infant
Infusions, Intravenous - nursing
Male
Pediatric Nursing - methods
Retrospective Studies
Tissue Plasminogen Activator - therapeutic use
Vascular Patency
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Summary:A 21-month retrospective review was completed at the Lucile Packard Children's Hospital to assess the experience of 22 infants and children who received alteplase for the clearance of occluded central venous access devices. After the first dose, 86% (n = 19) of the catheters cleared. Two additional catheters cleared with a second dose. With alteplase treatment, 95% (n = 21) of the catheters cleared. No adverse events were noted within 24 hours after the alteplase was received. Infusion of alteplase appeared to be safe and effective in restoring patency to occluded central venous access devices in infants and children.
ISSN:1533-1458
DOI:10.1097/00129804-200405000-00006