Hyperpolarization MRI: Preclinical Models and Potential Applications in Neuroradiology

ABSTRACTHyperpolarization is a novel technology that can dramatically increase signal to noise in magnetic resonance. The method is being applied to small injectable endogenous molecules, which can be used to monitor transient in vivo metabolic events, in real time. The emergence of hyperpolarized C...

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Bibliographic Details
Published inTopics in magnetic resonance imaging Vol. 25; no. 1; pp. 31 - 37
Main Authors Miloushev, Vesselin Z, Keshari, Kayvan R, Holodny, Andrei I
Format Journal Article
LanguageEnglish
Published United States Copyright Wolters Kluwer Health, Inc. All rights reserved 01.02.2016
Subjects
Brain - anatomy & histology
Brain - metabolism
Computer Simulation
Humans
Image Interpretation, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Models, Neurological
Molecular Imaging - methods
Radiopharmaceuticals - pharmacokinetics
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Summary:ABSTRACTHyperpolarization is a novel technology that can dramatically increase signal to noise in magnetic resonance. The method is being applied to small injectable endogenous molecules, which can be used to monitor transient in vivo metabolic events, in real time. The emergence of hyperpolarized C-labeled probes, specifically C pyruvate, has enabled monitoring of core cellular metabolic events. Neuro-oncological applications have been demonstrated in preclinical models. Many more applications of this technology are envisioned, with transformative potential in magnetic resonance imaging.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0899-3459
1536-1004
DOI:10.1097/RMR.0000000000000076