On the mapping of QTL by regression of phenotype on marker-type

We consider the properties of the regression of phenotype on marker-type in F sub(2) and backcross populations. We show that this regression provides exactly the same information about the location and effect of QTL as conventional regression mapping. For certain QTL configurations this information...

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Bibliographic Details
Published inHeredity Vol. 77; no. 1; pp. 23 - 32
Main Authors WHITTAKER, J. C, THOMPSON, R, VISSCHER, P. M
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing 01.07.1996
Subjects
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Methods, theories and miscellaneous
Genetic mapping
Vegetals
Statistical analysis
Genetic marker
Quantitative character
Backcross
Chromosome
Regression analysis
Phenotype
Gene
Animal
F2 hybrid
Mathematical model
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Summary:We consider the properties of the regression of phenotype on marker-type in F sub(2) and backcross populations. We show that this regression provides exactly the same information about the location and effect of QTL as conventional regression mapping. For certain QTL configurations this information is insufficient to map the QTL. Where the QTL can be mapped, the position and effect of QTL can be estimated directly from the coefficients of the regression of phenotype on marker-type. This requires much less computational effort than conventional regression mapping. Examples are given to illustrate the development of the theory.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0018-067X
1365-2540
DOI:10.1038/hdy.1996.104