Enantiospecific CH Activation Using Ruthenium Nanocatalysts
The activation of CH bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific CH activation has been developed to date. We herein report an enantiospecific CH activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic s...
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Published in | Angewandte Chemie Vol. 127; no. 36; pp. 10620 - 10623 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English German |
Published |
Weinheim
WILEY-VCH Verlag
01.09.2015
WILEY‐VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | The activation of CH bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific CH activation has been developed to date. We herein report an enantiospecific CH activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α‐position of the directing heteroatom results from a four‐membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles.
Verschiedene Verbindungen, wie Amine, Aminosäuren und Peptide, können in Gegenwart eines Ruthenium‐Nanokatalysators unter milden Bedingungen enantiospezifisch C‐H‐aktiviert und deuteriert werden. Berechnungen ergeben einen viergliedrigen Dimetallacyclus als Schlüsselintermediat und zeigen, dass die kollektive Bewegung von Oberflächenmolekülen durch Modifizieren der lokalen elektronischen Struktur die C‐H‐Aktivierung erleichtert. |
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Bibliography: | Grand Equipement National de Calcul Intensif - No. 6211 HPCs CALcul en Midi-Pyrénées - No. P0611 istex:27197CC5049D5F50C6922A29599D28C4C8F57AE5 ArticleID:ANGE201504554 ark:/67375/WNG-6TK11TVR-N ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0044-8249 1521-3757 |
DOI: | 10.1002/ange.201504554 |