Hydrophobicity profiles for protein sequence analysis

Hydrophobic interactions are a major force in protein folding and numerous hydropathy scales have been developed to quantify the relative hydrophobicity of the amino acids. Hydropathy profiles can be used to examine the surface features of proteins in order to generate hypotheses that can be confirm...

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Bibliographic Details
Published inCurrent protocols in protein science Vol. Chapter 2; p. Unit2.2
Main Authors Krystek, Jr, S R, Metzler, W J, Novotny, J
Format Journal Article
LanguageEnglish
Published United States 01.05.2001
Subjects
Hydrophobic and Hydrophilic Interactions
Proteins - chemistry
Proteins - genetics
Sequence Analysis, Protein - methods
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Summary:Hydrophobic interactions are a major force in protein folding and numerous hydropathy scales have been developed to quantify the relative hydrophobicity of the amino acids. Hydropathy profiles can be used to examine the surface features of proteins in order to generate hypotheses that can be confirmed experimentally. This unit describes the application of hydrophobicity plots to typical problems and provides suggested uses for a few selected scales.
ISSN:1934-3663
DOI:10.1002/0471140864.ps0202s00