Annular elastolytic giant cell granuloma after COVID-19 vaccination

The pandemic of SARS-CoV-2 during the first years of the 2020s led to a great commitment to develop effective vaccines. Despite of the good safety and tolerability profile, vaccines may trigger a broad spectrum of cutaneous side effects. Granulomatous dermatitis has been rarely reported after SARS-C...

Full description

Saved in:
Bibliographic Details
Published inDermatology reports Vol. 16; no. 3; p. 9811
Main Authors Lora, Viviana, Lamberti, Arianna, Di Prete, Monia, Graceffa, Dario, Cota, Carlo
Format Journal Article
LanguageEnglish
Published PAGEPress Publications, Pavia, Italy 12.09.2023
PAGEPress Publications
Subjects
Case Report
COVID-19 vaccination
elastic fibers
elastophagocytosis
granulomatous dermatitis
mid-dermal elastolysis
Online AccessGet full text

Cover

More Information
Summary:The pandemic of SARS-CoV-2 during the first years of the 2020s led to a great commitment to develop effective vaccines. Despite of the good safety and tolerability profile, vaccines may trigger a broad spectrum of cutaneous side effects. Granulomatous dermatitis has been rarely reported after SARS-CoV-2 mRNA vaccines, but no cases of annular elastolytic giant cell granuloma have been already described. Moreover, in our case, it was also associated with a central area of mid-dermal elastolysis, confirming the strong association between these two diseases already reported in literature. The observation of occasional eosinophils within the infiltrate and the presentation of the cutaneous eruption few days after the administration of the second dose of Pfizer/BioNTech (BNT162b2) vaccine are highly suggestive of a drug-related eruption. To our knowledge, this is the first report in literature of an annular elastolytic giant cell granuloma as an adverse effect of SARS-CoV-2 vaccination.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
Patient consent for publication: the patient signed a written informed consent to publication.
Publisher's note: all claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Ethics approval and consent to participate: not required. The study has been conducted in accordance with the Helsinki Declaration.
Conflict of interest: the authors declare no potential conflict of interest.
ISSN:2036-7392
2036-7406
DOI:10.4081/dr.2023.9811