NME1 functions as a metastasis suppressor in pancreatic cancer

Background A known metastasis suppressor gene, NME1 (Nm23), downregulated in melanoma, breast cancer, and other cancers, suppresses migration and invasion of tumor cells. However, in pancreatic cancer (PC), one of the common and deadly cancers worldwide that largely eludes early diagnosis, NME1 func...

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Published inMolecular & cellular toxicology Vol. 19; no. 4; pp. 767 - 773
Main Authors Kim, Do Yeon, Yun, Hyeseon, You, Ji-Eun, Koh, Dong-In, Ryu, Yea Seong, Yoon, Dong-Il, Kim, Chul Hee, Lee, Ji-U, Kang, Dong- Hee, Jin, Dong-Hoon
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 01.10.2023
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Cell Biology
Cell death
Cell proliferation
Life Sciences
MAP kinase
Melanoma
Metastases
Nucleoside-diphosphate kinase
Original Article
Pancreatic cancer
Pharmacology/Toxicology
Pheochromocytoma cells
Signal transduction
Therapeutic targets
Tumor cells
Western blotting
Tumor suppressor
Pancreatic cancer
Metastasis
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Summary:Background A known metastasis suppressor gene, NME1 (Nm23), downregulated in melanoma, breast cancer, and other cancers, suppresses migration and invasion of tumor cells. However, in pancreatic cancer (PC), one of the common and deadly cancers worldwide that largely eludes early diagnosis, NME1 function remains unstudied, prompting us to investigate its role. Objective The aim of this study is to investigate biological function of NME1 in pancreatic cancer growth and metastasis and explored potential mechanism mediated by MAPK/JNK signaling pathway. Results Western blots showed lower NME1 expression in pancreatic tumors than in normal tissues, while its overexpression in cultured PC cells induced cell death and inhibited proliferation, growth, migration, and invasion. NME1 was also found involved in multiple signaling pathways that confer metastatic properties. Conclusion This study identifies the important potential of NME1 in pancreatic cancer cells and role of novel biomarker and/or therapeutic target.
ISSN:1738-642X
2092-8467
DOI:10.1007/s13273-022-00305-2