A highly sensitive chloramphenicol detection sensor based on a carbon-graphite nanocomposite modified with silver nanoparticles application: human serum and urine

• Published in: Monatshefte für Chemie Vol. 154; no. 8; pp. 837 - 848
• Main Authors: Zoubir, Jallal, Elkhotfi, Yassine, Tounsi, Abdessamad, Assabbane, Ali, Bakas, Idriss
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.08.2023; Springer Nature B.V
• Subjects: Analytical Chemistry; Carbon; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Chloromycetin; Electrodes; Graphite; Inorganic Chemistry; Nanocomposites; Nanoparticles; Organic Chemistry; Original Paper; Physical Chemistry; Reproducibility; Silver; Theoretical and Computational Chemistry; Urine; Chloramphenicol; Electroanalysis; Electro-catalyst; Sensors; Human urine and serum
• ISSN: 0026-9247; 1434-4475
• DOI: 10.1007/s00706-023-03090-3

A highly sensitive Ag NPs@CPE sensor based on a carbon–graphite nanocomposite modified with silver nanoparticles was developed for the electrochemical determination of a drug, the antibiotic chloramphenicol. Electrochemical tests showed that the Ag NPs@CPE electrode had a higher electrochemical activity and a larger effective surface area than the bare electrode. X-ray diffraction and scanning electron microscopy demonstrated the presence of carbon-supported silver particles with a narrow size distribution, providing evidence for the effect of particle size on the electrocatalytic detection efficiency of chloramphenicol. Under optimal conditions, the modified Ag NPs@CPE electrode exhibited an excellent response at the linear detection range was 1.0 × 10 –3 –1.0 × 10 –7  mol/dm 3 and a detection limit of 6.19 × 10 –8  mol/dm 3 . The RSD values are 2.66% for repeatability and 3.02% for reproducibility. The proposed sensor provides remarkable selectivity and satisfactory recovery for real chloramphenicol-contaminated human urine and serum samples. Graphical abstract