New naphthyl derivatives from Aspergillus californicus

• Published in: Journal of antibiotics Vol. 74; no. 2; pp. 111 - 114
• Main Authors: Guo, Yaojie, Ghidinelli, Simone, de la Cruz, Mercedes, Mackenzie, Thomas A, Ramos, Maria C, Sánchez, Pilar, Vicente, Francisca, Genilloud, Olga, Larsen, Thomas O
• Format: Journal Article
• Language: English
• Published: Japan Nature Publishing Group 01.02.2021
• Subjects: Antibiotics; Cytotoxicity; Gram-positive bacteria; Staphylococcus infections
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/s41429-020-00372-4

Two new naphthyl-products calinaphthyltriol A (1) and calinaphthalenone A (2) were isolated from Aspergillus californicus IBT 16748 together with one known compound ophiobolin X (3). Their structures were elucidated by extensive spectroscopic analyses. The absolute configuration of 2 was solved by comparing its optical rotation with data for the known compounds 4, 5, and 6 as well as theoretical calculations. The antibacterial and cytotoxic activities of 1 and 3 were evaluated. Both compounds did not show antibacterial activity (MIC > 96 µg·ml ) against a few selected clinically relevant Gram positive and Gram negative bacterial strains. However, they showed moderate cytotoxicity against HL-60 cell line with IC values of 18 and 24 µg·ml , respectively.