Relationship of HbA1c with plasma atherogenic index and non-HDL cholesterol in patients with type 2 diabetes mellitus

• Published in: International journal of diabetes in developing countries Vol. 41; no. 2; pp. 302 - 306
• Main Authors: Bozkur, Evin, Esen, Ayse, Polat, Ozlem, Okuturlar, Yildiz, Akdeniz, Yasemin Sefika, Piskinpasa, Hamide, Dogansen, Sema, Cakir, Ilkay, Mert, Meral
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.06.2021; Springer Nature B.V
• Subjects: Arteriosclerosis; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Coronary artery disease; Diabetes; Diabetes mellitus (non-insulin dependent); Family Medicine; General Practice; Glucose; Health Administration; Heart diseases; Hemoglobin; High density lipoprotein; Lipoproteins; Low density lipoprotein; Medicine; Medicine & Public Health; Original Article; Risk factors; Diabetes mellitus; Plasma atherogenic index; Non-HDL cholesterol
• ISSN: 0973-3930; 1998-3832
• DOI: 10.1007/s13410-020-00884-7

Purpose Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular diseases (CVD). The plasma atherogenic index (PAI) has been suggested as a novel marker of atherosclerosis and coronary heart disease. The present study is conducted to investigate the relationship between glycated hemoglobin (HbA1c), non-HDL (high-density lipoprotein) cholesterol, and atherogenic index within patients with T2DM. Materials and methods A total of 4252 patients with T2DM were screened retrospectively and parameters including glucose, HbA1c, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, TSH, age, and gender were recorded. Non-HDL cholesterol and PAI were calculated as follows: PAI = TG ÷ HDL cholesterol non − HDL = total cholesterol − HDL cholesterol Results Mean age was 57.06 ± 11.39 years. Mean HbA1c was 8.49 ± 1.86%, PAI ratio was 4.12 ± 3.88 mg/dl, and mean non-HDL cholesterol was 156.50 ± 45.39 mg/dl. Non-HDL cholesterol ( r  = 0.427; p  < 0.001), HbA1c ( r  = 0.163; p  < 0.001), and glucose ( r  = 0.154; p  < 0.001) showed a significantly positive correlation with PAI. Conclusion Although a respectable attention is drawn to non-HDL cholesterol based on the present data, PAI may have a stronger relationship with HbA1c in patients with T2DM. PAI may be beneficial in predicting patients who have high risk for CVD in clinical practice.