Correlation between insulin resistance score and daily total insulin dosage in patient with type 1 diabetes mellitus: a pilot study

• Published in: International journal of diabetes in developing countries Vol. 43; no. 1; pp. 113 - 117
• Main Authors: Okada, Shuichi, Watanabe, Takuya, Okada, Junichi, Yamada, Eijiro, Okada, Kazuya, Kikkawa, Koji, Ohsima, Kihachi
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.02.2023; Springer Nature B.V
• Subjects: Body mass index; Diabetes; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Dosage; Family Medicine; General Practice; Health Administration; Hemoglobin; Insulin; Insulin resistance; Medicine; Medicine & Public Health; Patients; Short Article; Insulin resistance; Insulin therapy; Insulin resistance score; Type 1 diabetes mellitus
• ISSN: 0973-3930; 1998-3832
• DOI: 10.1007/s13410-022-01117-9

Purpose of the study Although insulin resistance is the pathogenic basis of type 2 diabetes mellitus (T2DM), it can also affect patients with type 1 diabetes mellitus (T1DM). In this clinical study, we investigated the relationship between insulin resistance grade and daily insulin dosage in order to clarify whether the approach to improving insulin resistance along with insulin therapy should be considered to treat T1DM and T2DM. Methods As the means of insulin resistance estimation, we selected the insulin resistance score because patients use insulin therapy and homeostatic model assessment insulin resistance (HOMA-IR) is not appropriate for those patients. The insulin resistance score was calculated as 24.31 – (12.22 × WHR) – (3.29 × HT) – (0.57 × HbA1c), where WHR is the waist-to-hip ratio, HT is hypertension, and HbA1c is glycated hemoglobin (%). Results The insulin resistance score was negatively correlated with the body mass index (BMI; r = –0.511) and the WHR (r = –0.773). The total insulin dosage was positively correlated with the BMI ( r = 0.734) but negatively correlated with the insulin resistance score ( r = –0.540). Conclusion Insulin resistance estimation is necessary for T1DM treatment, and the insulin resistance score is a useful tool for estimating insulin resistance in patients with T1DM accompanied with insulin resistance.