PTOV1 Expression Predicts Prostate Cancer in Men with Isolated High-Grade Prostatic Intraepithelial Neoplasia in Needle Biopsy
Purpose: To analyze the expression of PTOV1 in high-grade prostatic intraepithelial neoplasia (HG-PIN) and to explore its usefulness to predict prostate cancer in patients with isolated HG-PIN in needle biopsy (prostate needle biopsy). Experimental Design: PTOV1 expression in HG-PIN lesions from 140...
Saved in:
Published in | Clinical cancer research Vol. 14; no. 9; pp. 2617 - 2622 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Association for Cancer Research
01.05.2008
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Purpose: To analyze the expression of PTOV1 in high-grade prostatic intraepithelial neoplasia (HG-PIN) and to explore its usefulness
to predict prostate cancer in patients with isolated HG-PIN in needle biopsy (prostate needle biopsy).
Experimental Design: PTOV1 expression in HG-PIN lesions from 140 patients was analyzed by immunohistochemistry in a semiquantitative manner (Histo-score).
HG-PIN derived from 79 radical prostatectomies for prostate cancer and from 11 cistoprostatectomies for bladder cancer without
prostate cancer were used as positive and negative controls, respectively. Fifty patients with HG-PIN without concomitant
cancer at their first prostate needle biopsy were chosen as the study group. Patients were followed by a mean of 2.5 repeated
prostate needle biopsies (1-5), during a mean period of 12.4 months (1-39).
Results: PTOV1 expression in HG-PIN from radical prostatectomies showed a significantly higher Histo-score (162.6) compared with specimens
from cistoprostatectomies (67.0). In the study group, PTOV1 expression was significantly higher in samples with cancer in
the follow-up (11 patients, 22%) compared with samples in which cancer was not detected (151.4 versus 94.6). PTOV1 expression
was the only independent predictor of cancer in the multivariate analysis and the area under the curve was 0.803 (95% confidence
interval, 0.728-0.878). A threshold of 100 for PTOV1 expression provided 90.9% sensitivity, 51.3% specificity, 34.5% positive
predictive value, and 95.2% negative predictive value.
Conclusions: PTOV1 is overexpressed in HG-PIN associated with cancer and is a potential marker for studying the carcinogenesis and progression
of prostate cancer. Prostate needle biopsy with PTOV1 expression in HG-PIN above a threshold of 100 should be repeated immediately
for the likely presence of undiagnosed cancer. |
---|---|
ISSN: | 1078-0432 1557-3265 |
DOI: | 10.1158/1078-0432.CCR-07-4987 |