Square wave anodic adsorptive stripping voltammetric determination of cefpodoxime proxetil by using pencil graphite electrode

A new square wave anodic adsorptive stripping voltammetric method was developed to determine the cefpodoxime proxetil (CP) in pharmaceutics. A pencil graphite electrode was used as the electrode for direct electrochemical quantification of CP. pH 3.0, accumulation time 15 s, and accumulation potenti...

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Bibliographic Details
Published inMonatshefte für Chemie Vol. 152; no. 6; pp. 587 - 592
Main Author Erden, Sevcan
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 2021
Springer Nature B.V
Subjects
Accumulation
Adsorptivity
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Electrodes
Graphite
Inorganic Chemistry
Organic Chemistry
Original Paper
Pharmaceutical sciences
Physical Chemistry
Square waves
Stripping
Theoretical and Computational Chemistry
Voltammetry
Cyclic voltammetry
Electrochemistry
Voltammetry
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Summary:A new square wave anodic adsorptive stripping voltammetric method was developed to determine the cefpodoxime proxetil (CP) in pharmaceutics. A pencil graphite electrode was used as the electrode for direct electrochemical quantification of CP. pH 3.0, accumulation time 15 s, and accumulation potential 0.0 V were found as the optimum experimental conditions. Linear working range 1.0 × 10 –8  − 7.0 × 10 –7  M, the limit of detection 6.1 × 10 –9  M, and limit of quantification 2.0 × 10 –8  M were calculated. The matrix effects studies were tried. The developed method using pencil graphite electrode was successfully applied for the determination of CP assay in pharmaceutics. Graphic abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-021-02781-z