Solution combustion method for synthesis of ZnO NPs from Syzygium hemisphericum bark extract and a comparative analysis of the same with the crude bark extract for biomedical applications

• Published in: Chemical papers Vol. 78; no. 6; pp. 3443 - 3462
• Main Authors: Sushmitha, C. H., Krishnakumar, G., Navada, K. Meghana
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2024; Springer Nature B.V
• Subjects: Anticancer properties; Biochemistry; Biocompatibility; Biomedical materials; Biotechnology; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Comparative analysis; Glucosidase; Industrial Chemistry/Chemical Engineering; Infrared spectroscopy; Materials Science; Medicinal Chemistry; Nanoparticles; Original Paper; Reducing agents; Spectra; Ultrafines; Zinc oxide; Zinc oxides; ZnO nanostructures; GC–MS; Antibacterial; Skin cancer suppressor; Antidiabetic
• ISSN: 0366-6352; 1336-9075; 2585-7290
• DOI: 10.1007/s11696-024-03319-3

This study is aimed at the bio-fabrication of zinc oxide nanoparticles (SHB@ZnO NPs) from the aqueous bark extract of Syzygium hemisphericum (SHBW) and their comparative analysis for biomedical applications. The FT-IR spectra reveal the Zn–O bond by the appearance of peaks at 411 cm −1 and 398 cm −1 . Further, the peak at 370 nm in UV–Vis spectra analysis affirms the same. The X-ray diffraction reveals the ultrafine structure of NPs (10 nm). The morphology of the NPs depends on fuel load as analyzed from FESEM images. A prodigious antioxidant activity of SHBW was observed compared to ZnO NPs with IC 50 values of 8.877 ± 0.14 µg/mL and 236.74 ± 2.55 µg/mL, respectively. SHBW showed a markable α-amylase (37.68 ± 2.33 µg/mL) and α-glucosidase (37.68 ± 2.33 µg/mL) inhibitory activity compared to the SHB@ZnO-20. The antibacterial activity of synthesized NPs was observed against a wide range of strains. The HRBC membrane stabilization assay was carried out to substantiate the non-toxic nature toward human RBC’s (71.30% for SHBW and 46.96% for SHB@ZnO-20). The anticancer activity of ZnO NPs utilizing a definite volume of reducing agent was analyzed against A431 cancer cell lines which revealed that the cell viability decreased as NPs concentration (64.80% at 50 µg/mL) increased. Graphical abstract