The effect of amiloride on the metastatic properties of prostate cancer in the Dunning rat model

Most deaths from cancer result from the metastatic spread of the disease. The antidiuretic amiloride has been shown to inhibit tumor growth and metastasis in several tumor systems. The object of these studies was to examine the effect on the in vitro and in vivo tumor growth and metastasis in the Ma...

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Bibliographic Details
Published inOncology reports Vol. 5; no. 4; p. 889
Main Authors Pilat, M J, Lehr, J E, Quigley, M M, Pienta, K J
Format Journal Article
LanguageEnglish
Published Greece 01.07.1998
Subjects
Amiloride - therapeutic use
Animals
Antineoplastic Agents - therapeutic use
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Male
Neoplasm Invasiveness
Neoplasm Metastasis - prevention & control
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - pathology
Rats
Treatment Outcome
Tumor Cells, Cultured
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Summary:Most deaths from cancer result from the metastatic spread of the disease. The antidiuretic amiloride has been shown to inhibit tumor growth and metastasis in several tumor systems. The object of these studies was to examine the effect on the in vitro and in vivo tumor growth and metastasis in the MatLyLu subline of the Dunning model of rat prostate cancer. In vitro, amiloride was found to have cytotoxic effects only at high concentrations, with an IC50 of 100 microg/ml. In vitro analysis of the ability of amiloride to inhibit invasion of MLL cells demonstrated that this drug was ineffective at all concentrations examined. In vivo, amiloride did not inhibit tumor growth or metastases development. Our studies demonstrate that amiloride does not have activity in this model of prostate cancer and suggest it may not be an appropriate therapy for the treatment of prostate cancer.
ISSN:1021-335X
DOI:10.3892/or.5.4.889