Design of a Low Voltage TCNQ-Pd-Co@NC-Modified Electrode–Based NADH Sensor

• Published in: Electrocatalysis Vol. 15; no. 2-3; pp. 204 - 213
• Main Authors: Maurya, Kuldeep Kumar, Singh, Kulveer, Singh, Chitra, Malviya, Manisha
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2024; Springer Nature B.V
• Subjects: Adenine; Carbon; Catalysis; Chemical sensors; Chemistry; Chemistry and Materials Science; Cobalt; Design; Electrical measurement; Electrochemical impedance spectroscopy; Electrochemistry; Electrodes; Electron transfer; Energy Systems; Low voltage; Nanocomposites; Nicotinamide; Nicotinamide adenine dinucleotide; Oxidation; Palladium; Physical Chemistry; Sensitivity; Sensors; Voltammetry; Cyclic voltammetry; Electrocatalysis; Hydrothermal synthesis; Pd-Co@NC nanocomposite; NADH sensor
• ISSN: 1868-2529; 1868-5994
• DOI: 10.1007/s12678-024-00865-y

The present work involves the design and validation of an electrochemical sensor for precise and selective sensing of nicotinamide adenine dinucleotide (NADH). The designed electrochemical sensor consists of TCNQ and Pd-Co@NC nanocomposite–modified electrodes (TCNQ-Pd-Co@NC/CPE). The designed electrode was validated by cyclic voltammetry, amperometry, and electrochemical impedance spectroscopy (EIS). The results revealed potent electrocatalytic activity towards NADH oxidation and sensing. Cyclic voltammetry revealed the superior capability of TCNQ-Pd-Co@NC-based carbon paste electrode in electron transfer than TCNQ-Co@NC/CPE and TCNQ/CPE, validating better conductivity of TCNQ-Pd-Co@NC/CPE for NADH sensing. Amperometry study provided a wide linear range of 10 to 250 µM for NADH detection with a low detection limit (LOD) of 5.17 µM and a sensitivity of 21.5 µA mM. EIS study revealed the lowest R ct value of 12.5 × 10 2 for TCNQ-Pd-Co@NC/CPE compared to TCNQ-Co@NC/CPE and TCNQ/CPE, demonstrating high electron transfer capability and thus sensitivity towards NADH. Besides this, the modified TCNQ-Pd-Co@NC-based carbon paste electrodes offered exceptional selectivity, reproducibility, and stability over time. Therefore, designed TCNQ-Pd-Co@NC nanocomposite–based carbon paste electrodes can be efficiently used for precise and selective NADH sensing. Graphical Abstract