Low-Frequency Ultrasound Reinforces Silver Nanoparticles Effect in Experimental Chronic Non-healing Purulent Wounds Treatment

Managing chronic non-healing wounds (CNW) is a time-consuming process accompanied by economic loss. The combination of drug-resistant microflora that is able to organize in a biofilm is the main factor of wound chronicity that requires novel treatment strategies. The current study presents the resul...

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Published inBioNanoScience Vol. 13; no. 4; pp. 2337 - 2347
Main Authors Myronov, Petro, Duzhyi, Igor, Bugaiov, Volodymyr, Holubnycha, Viktoriia, Sikora, Vladyslav, Opanasyuk, Anatoliy, Romaniuk, Anatolii, Pererva, Oleksandr, Pogorielov, Maksym
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2023
Springer Nature B.V
Subjects
Biofilms
Biological and Medical Physics
Biomaterials
Biophysics
Cavitation
Chlorhexidine
Circuits and Systems
Drug resistance
Economic impact
Engineering
Granulation
Microflora
Nanoparticles
Nanotechnology
Necrosis
Regeneration (physiology)
Silver
Tissue engineering
Ultrasonic imaging
Ultrasound
Wound healing
Histology
Silver nanoparticles
Low-frequency ultrasound
Chronic non-healing wounds
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Summary:Managing chronic non-healing wounds (CNW) is a time-consuming process accompanied by economic loss. The combination of drug-resistant microflora that is able to organize in a biofilm is the main factor of wound chronicity that requires novel treatment strategies. The current study presents the results of silver nanoparticles (AgNPs) application accompanied by low-frequency ultrasound (US) in the rat model of a purulent CNW. As a result, using AgNPs and low-frequency US demonstrated positive dynamics of wound healing and a reduction in all phases of the wound process. The combined use of AgNPs and low-frequency US made it possible to reduce the time of necrosis rejection by 6.5 days ( p < 0.05), and the appearance of granulations and epithelial tissue by 3.7 and 4.7 days ( p < 0.05), respectively. Simultaneous treatment by the AgNPs with low-frequency US of the purulent CNW showed accelerative tissue regeneration processes, compared to separate AgNPs or US and chlorhexidine treatment methods. A synchronous application of AgNPs with US treatment significantly improves chronic purulent wound healing and reduces the treatment period. The effectiveness of the treatment method is achieved mainly due to the bactericidal properties of AgNPs and the cleansing effect of ultrasonic cavitation.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-023-01195-x