Exploring synthetic xanthone derivatives as potential anti-inflammatory agents: a comprehensive review

• Published in: Chemical papers Vol. 78; no. 13; pp. 7313 - 7333
• Main Authors: Ahmed, Lokman Ali, Deka, Babita, Sharmah, Hiyashree, Patowary, Pooja, Bharali, Deepsikha, Sahariah, Bhargab Jyoti, Talukdar, Apurba
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2024; Springer Nature B.V
• Subjects: Anti-inflammatory agents; Biochemistry; Biological properties; Biotechnology; Chemical synthesis; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Industrial Chemistry/Chemical Engineering; Materials Science; Medicinal Chemistry; Pharmacology; Review; Structural members; Xanthone; Synthetic; Anti-inflammatory; Xanthone derivatives
• ISSN: 0366-6352; 2585-7290; 1336-9075
• DOI: 10.1007/s11696-024-03614-z

In recent years, the exploration of natural compounds for their therapeutic potential has gained considerable attention, with xanthones emerging as promising candidates due to their diverse biological activities including anti-inflammatory properties. This comprehensive review delves into the synthesis and evaluation of synthetic xanthone derivatives as potential anti-inflammatory agents. The review commences by introducing the structural characteristics and chemical diversity of synthetic xanthone derivatives, highlighting the various methods used to synthesize them. It then delves into the mechanisms underlying the anti-inflammatory effects of synthetic xanthone derivatives, focusing on their interactions with key pathways involved in inflammation. Furthermore, the review explores the relationships between the structure of synthetic xanthones and their anti-inflammatory potential, shedding light on critical structural elements responsible for their efficacy. In summary, this review consolidates our existing knowledge about synthetic xanthone derivatives as a class of compounds with remarkable anti-inflammatory properties. It underscores the importance of further research to fully understand how they work, improve their pharmacological properties, and assess their clinical benefits. Synthetic xanthone derivatives show immense promise in the search for new anti-inflammatory therapeutics, making them a compelling subject for future drug development endeavors. Graphical abstract