Lung Cancer Cell Apoptosis Induced by Two New Trinuclear Cluster-Based Coordination Polymers

• Published in: Journal of inorganic and organometallic polymers and materials Vol. 33; no. 1; pp. 228 - 236
• Main Authors: Fu, Fang-Yong, Li, Yi-Jie, Lu, Wei, Li, Li, Wu, Cheng-De
• Format: Journal Article
• Language: English
• Published: New York Springer US 2023; Springer Nature B.V
• Subjects: Apoptosis; Chemistry; Chemistry and Materials Science; Coordination polymers; Dicarboxylic acids; Inorganic Chemistry; Lung cancer; Organic Chemistry; Polymer Sciences; Polymerase chain reaction; Single crystals; magnetic; apoptosis; luminescent; coordination polymer; ROS
• ISSN: 1574-1443; 1574-1451
• DOI: 10.1007/s10904-022-02466-y

Two coordination polymers, {[Cd 3 (2,4-pda) 4 (H 2 O) 2 ][(CH 3 ) 2 NH 2 ] 2 }n·2n(DMF) ( 1 ) and [Mn 3 (2,4-pda) 3 (H 2 O) 4 ]n ( 2 ), where 2,4-H 2 pda is pyridine-2,4-dicarboxylic acid, have been synthesized under solvothermal conditions and structurally characterized by single crystal X-ray diffraction. The solid state structure of both compounds is characterized by trinuclear metal entities, which expands to a 2D layer and 1D coordination polymer, respectively, thanks to the bridging behavior of 2,4-pda ligands. The luminescent performance of complex 1 and the magnetic activity of complex 2 were investigated. Their application towards the lung cancer was evaluated and the related mechanism was explored as well. Firstly, the levels of the apoptotic lung cancer cells, after treatment with compounds 1 and 2 , were determined by using the Annexin V-FITC kit. Compound 1 significantly increased the levels of apoptotic lung cancer cells, more efficiently than 2 . In addition, the relative expression of reactive oxygen species (ROS) related genes in the lung cancer cells were investigated with the real time reverse transcription-polymerase chain reaction (RT-PCR) assay. The levels of ROS significantly increased after treatment with compound 1 in comparison with 2 .