Urokinase stimulates differentiation of fibroblasts into myofibroblasts and their proliferation in damaged adventitia

Urokinase expression in the adventitia of rat common carotid artery increased on the 4th day after periadventitial damage. Periadventitial application of recombinant urokinase increased the area of the adventitia and the content of contractile and proliferating cells, while proteolytically inactive...

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Published inBulletin of experimental biology and medicine Vol. 129; no. 5; pp. 429 - 432
Main Authors Plekhanova, O S, Volynskaya, E A, Kalinina, N I, Parfenova, E V
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.05.2000
Subjects
Animals
Carotid Arteries - drug effects
Carotid Arteries - pathology
Carotid Arteries - physiopathology
Cell Differentiation - drug effects
Fibroblasts - drug effects
Fibroblasts - pathology
Male
Plasminogen Activators - pharmacology
Rats
Rats, Wistar
Recombinant Proteins - pharmacology
Urokinase-Type Plasminogen Activator - pharmacology
Vasoconstriction
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Summary:Urokinase expression in the adventitia of rat common carotid artery increased on the 4th day after periadventitial damage. Periadventitial application of recombinant urokinase increased the area of the adventitia and the content of contractile and proliferating cells, while proteolytically inactive recombinant urokinase was ineffective.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02439792