Histology of the bone marrow antibody response. An immunocytochemical study during the secondary response in mouse and rat

The histology of the specific and non-specific antibody response in mouse and rat bone marrow was studied after subcutaneous priming and intravenous boosting with horseradish peroxidase (HRP). Cells producing specific antibody against HRP were found only occasionally in the bone marrow after subcuta...

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Bibliographic Details
Published inVirchows Archiv. B, Cell pathology Vol. 44; no. 1; p. 65
Main Authors Geldof, A A, Rimmelzwaan, G F, Langevoort, H L
Format Journal Article
LanguageEnglish
Published Germany 1983
Subjects
Animals
Antibody Formation
Bone Marrow - analysis
Bone Marrow - immunology
Bone Marrow - ultrastructure
Cytoplasm - immunology
Female
Histocytochemistry
Horseradish Peroxidase - immunology
Immunoglobulins - analysis
Injections, Intravenous
Injections, Subcutaneous
Mice
Rats
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Summary:The histology of the specific and non-specific antibody response in mouse and rat bone marrow was studied after subcutaneous priming and intravenous boosting with horseradish peroxidase (HRP). Cells producing specific antibody against HRP were found only occasionally in the bone marrow after subcutaneous priming. After the intravenous boost injection their number gradually increased. These anti-HRP forming cells were found as single cells, randomly dispersed throughout the bone marrow. Such a random distribution was also found for cytoplasmic (non-specific) immunoglobulin containing cells. At no time point after immunization could lymphoid aggregates or trapping of immune complexes be observed in the bone marrow of either species. On the basis of these observations it is concluded that the bone marrow forms a suitable microenvironment for immigrating antibody-forming cells but does not contribute actively to the induction of the immune response.
ISSN:0340-6075
DOI:10.1007/BF02890160