The relationship between characteristics of the tumor cells and sex of the patients in primary malignant melanomas

Sex is a well proven prognosticator in primary malignant melanoma. We studied 19 parameters of tumor cells in primary malignant melanoma from 391 patients, the purpose being to determine if melanomas in men and women are alike. Apart from results in thin melanomas, no difference was seen between the...

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Bibliographic Details
Published inJournal of cancer research and clinical oncology Vol. 117; no. 4; p. 364
Main Authors Ostmeier, H, Schumann, J, Otto, F, Krieg, V, Fuchs, B, Biess, B, Burg, G, Suter, L
Format Journal Article
LanguageEnglish
Published Germany 01.01.1991
Subjects
Antigens, Neoplasm - analysis
Cell Division - physiology
Female
Humans
Male
Melanoma - genetics
Melanoma - pathology
Phenotype
Ploidies
Sex Characteristics
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Summary:Sex is a well proven prognosticator in primary malignant melanoma. We studied 19 parameters of tumor cells in primary malignant melanoma from 391 patients, the purpose being to determine if melanomas in men and women are alike. Apart from results in thin melanomas, no difference was seen between the sex groups. Thin melanomas showed a significant difference for the melanoma-associated antigen G7-E2 (higher expression in women) and the histocompatibility antigen HLA-DR (higher expression in men). The results suggest that sex-related prognostic differences are due more to host than to tumor characteristics.
ISSN:0171-5216
DOI:10.1007/BF01630721