Exploring the topical gel of Thespesia populnea leaf extract for in vivo wound healing efficacy

Background/Aim: Thespesia populnea is a plant known for its polyphenol and flavonoid content, which plays a crucial role in wound healing activity. Traditionally, extracts of various parts of T. populnea plant have been used to treat various skin diseases including wound healing. Therefore, we made...

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Published inPharmacognosy Magazine Vol. 18; no. 79; pp. 519 - 523
Main Authors Asif, Afzal, Mulla, Salim, Shariff, Arshia, Sreeharsha, Nagaraja, Meravanige, Girish, Shiroorkar, Predeepkumar, Basheeruddin Asdaq, Syed, Anwer, Md, Roopashree, Teeka, Karnati, Ranjith
Format Journal Article
LanguageEnglish
Published London Wolters Kluwer India Pvt. Ltd 01.07.2022
Medknow Publications and Media Pvt. Ltd
Sage Publications Ltd
Subjects
Antimicrobial agents
Bioflavonoids
Care and treatment
Flavones
Flavonoids
Medicine, Botanic
Medicine, Herbal
Skin diseases
Wound healing
Wounds and injuries
India
Antimicrobial
histopathology
wound healing
Thespesia populnea
gel
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Summary:Background/Aim: Thespesia populnea is a plant known for its polyphenol and flavonoid content, which plays a crucial role in wound healing activity. Traditionally, extracts of various parts of T. populnea plant have been used to treat various skin diseases including wound healing. Therefore, we made a topical gel containing alcoholic extracts of the leaves of T. populnea for antimicrobial and wound healing activities. Materials and Methods: Extracts of T. populnea were successfully obtained by Soxhlet extraction. Phytochemical screenings were performed to estimate the presence of different metabolites. Combinations of carbopol and propylene glycol were optimized through 32 factorial design for desirable gel characteristics. Results and Discussions: Formulated gel was pale brown in color having viscosity of 90,300 cps with acceptable spreadability and extrudability index. Antimicrobial studies showed inhibition activity. The in vivo wound healing studies demonstrated comparable healing properties with respect to marketed Soframycin gel. Furthermore, histopathological studies on Wistar rats also confirmed the same. Conclusion: It can be concluded that the formulated gel is beneficial in topical applications, which can be a beacon for new skin regeneration and wound healing therapies that focuses on herbal remediation.
ISSN:0973-1296
0976-4062
DOI:10.4103/pm.pm_25_22