Synthesis and Antiviral Activity of 1-Aryl-3-(3,5-Dioxo-4-Azatetracyclo-[5.3.2.02,6.08,10]Dodec-11-EN-4-YL)Ureas

A series of 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)urea derivatives were synthesized and studied for antiviral activity against smallpox vaccine virus. 3-(3,5-Dioxo-4-azatetracyclo-[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)-1-(4-methylphenyl)urea, 3-(3,5-dioxo-4-azate...

Full description

Saved in:
Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 51; no. 6; pp. 439 - 443
Main Authors Selivanov, B. A., Tikhonov, A. Y., Belanov, E. F., Bormotov, N. I., Kabanov, A. S., Mazurkov, O. Yu, Serova, O. A., Shishkina, L. N., Agafonov, A. P., Sergeev, A. N.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.09.2017
Springer
Subjects
Antiviral agents
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
0
smallpox vaccines
pharmacological activity
arylisocyanates
1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0
arylisothiocyanates
antiviral activity
dodec-11-en-4-yl)ureas
Online AccessGet full text

Cover

More Information
Summary:A series of 1-aryl-3-(3,5-dioxo-4-azatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)urea derivatives were synthesized and studied for antiviral activity against smallpox vaccine virus. 3-(3,5-Dioxo-4-azatetracyclo-[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)-1-(4-methylphenyl)urea, 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)-1-(3-fluorophenyl)urea hydrate, and 3-(3,5-dioxo-4-azatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-en-4-yl)-1-(phenyl)thiourea showed pronounced activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-017-1629-9