Cyclosporin A on human corneal endothelium

Human corneal endothelial cells grown in culture medium were exposed to different concentrations of cyclosporin A in vitro. After 7 days, concentrations of the drug less than 1,000 ng/ml of medium were found nontoxic to the endothelial layer, while greater concentrations killed the cells in 1 hour t...

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Bibliographic Details
Published inCornea Vol. 3; no. 4; p. 272
Main Authors Singh, G, Lindstrom, R L, Doughman, D J
Format Journal Article
LanguageEnglish
Published United States 1984
Subjects
Cornea - drug effects
Cyclosporins - poisoning
Endothelium - drug effects
Humans
In Vitro Techniques
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Summary:Human corneal endothelial cells grown in culture medium were exposed to different concentrations of cyclosporin A in vitro. After 7 days, concentrations of the drug less than 1,000 ng/ml of medium were found nontoxic to the endothelial layer, while greater concentrations killed the cells in 1 hour to 48 hours, depending upon the concentration of the drug. Degenerative cytoplasmic vacuoles were the first sign of toxicity from the drug, leading in higher concentrations to eventual disintegration.
ISSN:0277-3740
DOI:10.1097/00003226-198404000-00008