Discovery of new anticancer agents from higher plants

Small organic molecules derived from higher plants have been one of the mainstays of cancer chemotherapy for approximately the past half a century. In the present review, selected single chemical entity natural products of plant origin and their semi-synthetic derivatives currently in clinical trial...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in bioscience (Scholar edition) Vol. 4; no. 1; p. 142
Main Authors Pan, Li, Chai, Hee-Byung, Kinghorn, Alan Douglas
Format Journal Article
LanguageEnglish
Published Singapore 01.01.2012
Subjects
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - therapeutic use
Biological Products - chemistry
Biological Products - therapeutic use
Clinical Trials as Topic
Humans
Plant Extracts - chemistry
Plant Extracts - therapeutic use
Plants - chemistry
Online AccessGet more information

Cover

More Information
Summary:Small organic molecules derived from higher plants have been one of the mainstays of cancer chemotherapy for approximately the past half a century. In the present review, selected single chemical entity natural products of plant origin and their semi-synthetic derivatives currently in clinical trials are featured as examples of new cancer chemotherapeutic drug candidates. Several more recently isolated compounds obtained from plants showing promising in vivo biological activity are also discussed in terms of their potential as anticancer agents, with many of these obtained from species that grow in tropical regions. Since extracts of only a relatively small proportion of the ca. 300,000 higher plants on earth have been screened biologically to date, bioactive compounds from plants should play an important role in future anticancer drug discovery efforts.
ISSN:1945-0524
DOI:10.2741/s257