Studies on 2-Substituted Thiazolines. L. Reaction with Cyanoacetic Acid

• Published in: Chemical & pharmaceutical bulletin Vol. 21; no. 7; pp. 1426 - 1430
• Main Authors: SAKURAI, YOZIRO, KURUMI, MASATERU, OKUTOME, TOSHIYUKI, SATO, SHIGEO, YAMAGUCHI, KAZUTAKA
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1973; Japan Science and Technology Agency

2-Substituted thiazokines (IIa-d) were prepared from 2-thiothiazokidone. IIa-d were converted to 2-(ethoxycarbonylcyanomethylene) thiazolidine (III) and its N-acetate and N-methyl derivative. Thiolester analogs of III were obtained by the reaction of IIa-d and cyanoacetic acid in acetic anhydride.