Megastigmane Glycosides from Docynia indica and Their Anti-inflammatory Activities

• Published in: Helvetica chimica acta Vol. 99; no. 9; pp. 681 - 686
• Main Authors: Dung, Hoang Viet, Bach, Nguyen Van, Trung, Trinh Nam, Nhiem, Nguyen Xuan, Tai, Bui Huu, Kiem, Phan Van, Park, SeonJu, Lee, Taek Hwan, Kim, Sun Yeou, Kim, Seung Hyun
• Format: Journal Article
• Language: English
• Published: Zürich Blackwell Publishing Ltd 01.09.2016; Wiley Subscription Services, Inc
• Subjects: Anti-inflammatory activities; Docynia indica; Docynicasides A - C; Rosaceae
• ISSN: 0018-019X; 1522-2675
• DOI: 10.1002/hlca.201600125

Using various chromatographic methods, three new megastigmane glycosides, docynicasides A – C (1 – 3) and ten known, (6S,9R)‐vomifoliol 9‐O‐β‐d‐xylopyranosyl‐(1′′→6′)‐O‐β‐d‐glucopyranoside (4), hyperin (5), quercitrin (6), quercetin 3‐α‐l‐arabinofuranoside (7), naringenin 7‐O‐β‐d‐glucopyranoside (8), phloridzin (9), phloretin 2′‐O‐β‐d‐xylopyranosyl‐(1→6)‐β‐d‐glucopyranoside (10), pinosylvin 3‐O‐β‐d‐glucopyranoside (11), tormentic acid (12), and chlorogenic acid methyl ester (13) were isolated from the fruits of Docynia indica. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on NO production in LPS‐stimulated BV2 cells. As the results, compounds 3 – 5 showed significant inhibitory activity on LPS‐stimulated NO production in BV2 cells with the IC50 values ranging from 21.0 to 29.3 μm.