Anxiolytic and sedative effects of 5-HT1A ligands, 8-OH-DPAT and MDL 73005EF, in mice

The actions of the 5-HT1A receptor ligands, MDL 73005EF and 8-OH-DPAT, were assessed in mice. They were confronted with a free exploratory test especially adapted to reveal sedation, and with a two-box light/dark choice situation validated for the detection of anti-anxiety agents. Both drugs were fo...

Full description

Saved in:
Bibliographic Details
Published inNeuroreport Vol. 1; no. 3-4; p. 267
Main Authors Misslin, R, Griebel, G, Saffroy-Spittler, M, Vogel, E
Format Journal Article
LanguageEnglish
Published England 01.11.1990
Subjects
8-Hydroxy-2-(di-n-propylamino)tetralin
Animals
Anti-Anxiety Agents - pharmacology
Dioxins - pharmacology
Exploratory Behavior - drug effects
Hypnotics and Sedatives - pharmacology
Male
Mice
Receptors, Serotonin - drug effects
Spiro Compounds - pharmacology
Tetrahydronaphthalenes - pharmacology
Online AccessGet more information

Cover

More Information
Summary:The actions of the 5-HT1A receptor ligands, MDL 73005EF and 8-OH-DPAT, were assessed in mice. They were confronted with a free exploratory test especially adapted to reveal sedation, and with a two-box light/dark choice situation validated for the detection of anti-anxiety agents. Both drugs were found to have sedative properties at high doses and anxiolytic-like effects at lower doses. The results show that both drugs have a comparable profile of action to that of benzodiazepines in the two-box light/dark procedure. These findings are in line with earlier reports describing anxiolytic effects of 5-HT1A receptor ligands in different animal models of anxiety.
ISSN:0959-4965
DOI:10.1097/00001756-199011000-00025