Stability of Aminoglycoside Antibiotics in Anemopathy

Stability of aminoglycosides (AG) in anemopathy was investigated in regard to change in appearance and in pH, smell and residual potency by compatibility tests using Alevaire, and influence of ultrasonic nebulization. In this study, commercially available injections of gentamicin (GC), kanamycin (KC...

Full description

Saved in:
Bibliographic Details
Published inByōin yakugaku Vol. 11; no. 1; pp. 32 - 44
Main Authors MURASE, SETSUKO, TAKEUCHI, HISAKO, MICHIMORI, MOTOKO, TOMONAGA, FUMIYA
Format Journal Article
LanguageJapanese
English
Published Japanese Society of Pharmaceutical Health Care and Sciences 1985
Subjects
additives
aminoglycoside antibiotics
anemopathy
smell
stability
ultrasonic nebulization
Online AccessGet full text

Cover

More Information
Summary:Stability of aminoglycosides (AG) in anemopathy was investigated in regard to change in appearance and in pH, smell and residual potency by compatibility tests using Alevaire, and influence of ultrasonic nebulization. In this study, commercially available injections of gentamicin (GC), kanamycin (KC), streptomycin (SC), amikacin (BK), dibekacin (PM) and tobramycin (TC) were used. The results are summarized as follows: 1) No changes in appearance and pH were observed in all the solutions of AG mixed with Alevaire. BK and PM kept primary potency for 168 hours after mixing, but the potency of GC began to decrease 24 hours after, and also that of KC, SC and TC decreased slightly 6 to 168 hours after. 2) AG was stable even under the influence of ultrasonic nebulization, though a bad smell was given out from additives in AG injections due to their decomposition. From these results, it is emphasized that: 1) AG should be mixed just before use, and 2) attention should be paid to odor and taste, as well as residual potency.
ISSN:0389-9098
2185-9477
DOI:10.5649/jjphcs1975.11.32