Rare Presentation of Prostate Cancer Mimicking Malignant Lymphoma with Generalized Lymphadenopathy

Abstract Prostate cancer typically metastasizes to bones and regional lymph nodes. Generalized lymphadenopathy is a rare manifestation of metastatic prostate cancer. We report a case of prostate cancer in a 65-year-old male with initial presentation of generalized lymphadenopathy and no urinary symp...

Full description

Saved in:
Bibliographic Details
Published inJournal of cancer research and practice Vol. 1; no. 1; pp. 70 - 74
Main Authors Tsai, Yu-Fen, Cho, Shih-Feng, Wu, Chun-Chieh, Liu, Ta-Chih
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.06.2014
Wolters Kluwer Medknow Publications
Subjects
generalized lymphadenopathy
Hematology, Oncology and Palliative Medicine
malignant lymphoma
prostate cancer
generalized lymphadenopathy
malignant lymphoma
prostate cancer
Online AccessGet full text

Cover

Abstract Abstract Prostate cancer typically metastasizes to bones and regional lymph nodes. Generalized lymphadenopathy is a rare manifestation of metastatic prostate cancer. We report a case of prostate cancer in a 65-year-old male with initial presentation of generalized lymphadenopathy and no urinary symptoms. Lymph node biopsy revealed metastatic adenocarcinoma, and immunohistochemical staining was positive for prostate-specific antigen (PSA) compatible with a prostatic origin. Directed biopsy confirmed that the tumor originated in the prostate. Therefore, the prostate should be considered a possible origin of metastatic adenocarcinoma in men, and presentations consistent with generalized lymphadenopathy cannot exclude a diagnosis of prostate cancer.
AbstractList Abstract Prostate cancer typically metastasizes to bones and regional lymph nodes. Generalized lymphadenopathy is a rare manifestation of metastatic prostate cancer. We report a case of prostate cancer in a 65-year-old male with initial presentation of generalized lymphadenopathy and no urinary symptoms. Lymph node biopsy revealed metastatic adenocarcinoma, and immunohistochemical staining was positive for prostate-specific antigen (PSA) compatible with a prostatic origin. Directed biopsy confirmed that the tumor originated in the prostate. Therefore, the prostate should be considered a possible origin of metastatic adenocarcinoma in men, and presentations consistent with generalized lymphadenopathy cannot exclude a diagnosis of prostate cancer.
Prostate cancer typically metastasizes to bones and regional lymph nodes. Generalized lymphadenopathy is a rare manifestation of metastatic prostate cancer. We report a case of prostate cancer in a 65-year-old male with initial presentation of generalized lymphadenopathy and no urinary symptoms. Lymph node biopsy revealed metastatic adenocarcinoma, and immunohistochemical staining was positive for prostate-specific antigen (PSA) compatible with a prostatic origin. Directed biopsy confirmed that the tumor originated in the prostate. Therefore, the prostate should be considered a possible origin of metastatic adenocarcinoma in men, and presentations consistent with generalized lymphadenopathy cannot exclude a diagnosis of prostate cancer.
Author Wu, Chun-Chieh
Tsai, Yu-Fen
Cho, Shih-Feng
Liu, Ta-Chih
Author_xml – sequence: 1
  fullname: Tsai, Yu-Fen
– sequence: 2
  fullname: Cho, Shih-Feng
– sequence: 3
  fullname: Wu, Chun-Chieh
– sequence: 4
  fullname: Liu, Ta-Chih
BookMark eNqFkE1r3DAQhkVIIR_NTwj4mB6caGRbXl9awtKmgQ0t_TiLsTTa1cYrLZLTsvn11a5DKL30NHpnmIfRc8aOffDE2CXwa-Agb76LCqCsOJdXIN_lKtoSjtjpa_v4r_cJu0hpzTmHToi6rU9Z_w0jFV8jJfIjji74IticQ8qJijl6TbF4cBunH51fFg84uKVHPxaL3Wa7ChssfrtxVdyRp5hnz2SmCRryYYvjaveWvbE4JLp4qefs56ePP-afy8WXu_v57aLUouVQEpkWCKG3FjjJrhHQN9w2IAyablZXiDNTQ93PWjsznUWsRG8qIbTpBXFenbP7iWsCrtU2ug3GnQro1KER4lJhHJ0eSAmybWMlSLR9DUZi1dWdkFa0sm8115nVTCydTaRI9pUHXO29q4N3tZeqcjp4V5D3Pkx7lD_6y1FUSTvKDo2LpMd8ifsv4f0_BD047zQOj7SjtA5P0WeLClQSik-QPQPkgQDVHxxioZo
Cites_doi 10.1056/NEJM199104253241702
10.1097/00000478-198706000-00006
10.1016/S0090-4295(96)00511-0
10.1001/jama.279.19.1542
10.2214/AJR.11.7533
10.1002/1097-0142(19841215)54:12<3078::AID-CNCR2820541245>3.0.CO;2-U
10.1016/S0022-5347(17)52913-4
10.1001/jama.1995.03530150038031
10.1007/s00405-006-0066-2
10.1053/hp.2000.6698
ContentType Journal Article
Copyright The Chinese Oncology Society
2014 The Chinese Oncology Society
Copyright_xml – notice: The Chinese Oncology Society
– notice: 2014 The Chinese Oncology Society
DBID 6I.
AAFTH
AAYXX
CITATION
DOA
DOI 10.1016/S2311-3006(16)30027-1
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
DatabaseTitleList


Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2311-3006
EndPage 74
ExternalDocumentID oai_doaj_org_article_2ef75f616afb41d6a394926f276b7c0c
10_1016_S2311_3006_16_30027_1
S2311300616300271
1_s2_0_S2311300616300271
GroupedDBID 0R~
0SF
1P~
5VS
9RA
AACTN
AAEDW
AALRI
AAXUO
ABMAC
ACGFS
ADEZE
ADVLN
AEVXI
AGHFR
AITUG
AKRWK
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
EBS
EJD
FDB
GROUPED_DOAJ
H13
IAO
IHR
IPNFZ
ITC
KQ8
NCXOZ
O9-
OK1
OVD
RIG
RMW
ROL
SSZ
TEORI
W3E
Z5R
6I.
AAFTH
AAYXX
CITATION
ID FETCH-LOGICAL-c2701-eed71ea1bff10e69521b50f512dad9843aa8d414b87f8d9faa32bd322cdb2e003
IEDL.DBID DOA
ISSN 2311-3006
IngestDate Tue Oct 22 15:09:45 EDT 2024
Thu Sep 26 17:31:51 EDT 2024
Fri Feb 23 02:18:48 EST 2024
Tue Oct 15 22:55:59 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords generalized lymphadenopathy
malignant lymphoma
prostate cancer
Language English
License http://creativecommons.org/licenses/by-nc-nd/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c2701-eed71ea1bff10e69521b50f512dad9843aa8d414b87f8d9faa32bd322cdb2e003
OpenAccessLink https://doaj.org/article/2ef75f616afb41d6a394926f276b7c0c
PageCount 5
ParticipantIDs doaj_primary_oai_doaj_org_article_2ef75f616afb41d6a394926f276b7c0c
crossref_primary_10_1016_S2311_3006_16_30027_1
elsevier_sciencedirect_doi_10_1016_S2311_3006_16_30027_1
elsevier_clinicalkeyesjournals_1_s2_0_S2311300616300271
PublicationCentury 2000
PublicationDate June 2014
PublicationDateYYYYMMDD 2014-06-01
PublicationDate_xml – month: 06
  year: 2014
  text: June 2014
PublicationDecade 2010
PublicationTitle Journal of cancer research and practice
PublicationYear 2014
Publisher Elsevier B.V
Wolters Kluwer Medknow Publications
Publisher_xml – name: Elsevier B.V
– name: Wolters Kluwer Medknow Publications
References Catalona, Smith, Wolfert (bib3) 1995; 274
Vashi, Wojno, Henricks (bib5) 1997; 49
Cho, Epstein (bib1) 1987; 11
Catalona, Partin, Slawin (bib4) 1998; 279
Hematpour, Bennett, Rogers (bib7) 2006; 263
Lindell, Doubleday, von Eschenbach (bib8) 1982; 128
Catalona, Smith, Ratliff (bib2) 1991; 324
Vinjamoori, Jagannathan, Shinagare (bib10) 2012; 199
Bubendorf, Schöpfer, Wagner (bib9) 2000; 31
Saitoh, Hida, Shimbo (bib6) 1984; 54
Bubendorf (10.1016/S2311-3006(16)30027-1_bib9) 2000; 31
Catalona (10.1016/S2311-3006(16)30027-1_bib3) 1995; 274
Vinjamoori (10.1016/S2311-3006(16)30027-1_bib10) 2012; 199
Hematpour (10.1016/S2311-3006(16)30027-1_bib7) 2006; 263
Cho (10.1016/S2311-3006(16)30027-1_bib1) 1987; 11
Catalona (10.1016/S2311-3006(16)30027-1_bib4) 1998; 279
Catalona (10.1016/S2311-3006(16)30027-1_bib2) 1991; 324
Saitoh (10.1016/S2311-3006(16)30027-1_bib6) 1984; 54
Lindell (10.1016/S2311-3006(16)30027-1_bib8) 1982; 128
Vashi (10.1016/S2311-3006(16)30027-1_bib5) 1997; 49
References_xml – volume: 128
  start-page: 331
  year: 1982
  end-page: 334
  ident: bib8
  article-title: Mediastinal metastases from prostatic carcinoma
  publication-title: J Urol
  contributor:
    fullname: von Eschenbach
– volume: 263
  start-page: 872
  year: 2006
  end-page: 874
  ident: bib7
  article-title: Supraclavicular lymph node : incidence of unsuspected metastatic prostate cancer
  publication-title: Eur Arch Otorhinolaryngol
  contributor:
    fullname: Rogers
– volume: 199
  start-page: 67
  year: 2012
  end-page: 372
  ident: bib10
  article-title: Atypical metastases from prostate cancer: 10-year experience at a single institution
  publication-title: AJR Am J Roentgenol
  contributor:
    fullname: Shinagare
– volume: 274
  start-page: 1214
  year: 1995
  end-page: 1220
  ident: bib3
  article-title: Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening
  publication-title: JAMA
  contributor:
    fullname: Wolfert
– volume: 49
  start-page: 19
  year: 1997
  end-page: 27
  ident: bib5
  article-title: Determination of the “reflex range” and appropriate cutpoints for percent free prostate-specific antigen in 413 men referred for prostatic evaluation using the AxSYM system
  publication-title: Urology
  contributor:
    fullname: Henricks
– volume: 11
  start-page: 457
  year: 1987
  end-page: 463
  ident: bib1
  article-title: Metastatic prostate carcinoma to supradiaphragmatic lymph nodes: a clinicopathologic and immunohistochemical study
  publication-title: Am J Surg Pathol
  contributor:
    fullname: Epstein
– volume: 54
  start-page: 3078
  year: 1984
  end-page: 3084
  ident: bib6
  article-title: Metastatic patterns of prostatic cancer. Correlation between sites and number of organs involved
  publication-title: Cancer
  contributor:
    fullname: Shimbo
– volume: 31
  start-page: 578
  year: 2000
  end-page: 583
  ident: bib9
  article-title: Metastatic patterns of prostate cancer: an autopsy study of 1.589 patients
  publication-title: Hum Pathol
  contributor:
    fullname: Wagner
– volume: 324
  start-page: 1156
  year: 1991
  end-page: 1161
  ident: bib2
  article-title: Measurement of prostate-specific antigen in serum as a screening test for prostate cancer
  publication-title: N Engl J Med
  contributor:
    fullname: Ratliff
– volume: 279
  start-page: 1542
  year: 1998
  end-page: 1547
  ident: bib4
  article-title: Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial
  publication-title: JAMA
  contributor:
    fullname: Slawin
– volume: 324
  start-page: 1156
  issue: 17
  year: 1991
  ident: 10.1016/S2311-3006(16)30027-1_bib2
  article-title: Measurement of prostate-specific antigen in serum as a screening test for prostate cancer
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199104253241702
  contributor:
    fullname: Catalona
– volume: 11
  start-page: 457
  issue: 6
  year: 1987
  ident: 10.1016/S2311-3006(16)30027-1_bib1
  article-title: Metastatic prostate carcinoma to supradiaphragmatic lymph nodes: a clinicopathologic and immunohistochemical study
  publication-title: Am J Surg Pathol
  doi: 10.1097/00000478-198706000-00006
  contributor:
    fullname: Cho
– volume: 49
  start-page: 19
  issue: 1
  year: 1997
  ident: 10.1016/S2311-3006(16)30027-1_bib5
  article-title: Determination of the “reflex range” and appropriate cutpoints for percent free prostate-specific antigen in 413 men referred for prostatic evaluation using the AxSYM system
  publication-title: Urology
  doi: 10.1016/S0090-4295(96)00511-0
  contributor:
    fullname: Vashi
– volume: 279
  start-page: 1542
  issue: 19
  year: 1998
  ident: 10.1016/S2311-3006(16)30027-1_bib4
  article-title: Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial
  publication-title: JAMA
  doi: 10.1001/jama.279.19.1542
  contributor:
    fullname: Catalona
– volume: 199
  start-page: 67
  issue: 2
  year: 2012
  ident: 10.1016/S2311-3006(16)30027-1_bib10
  article-title: Atypical metastases from prostate cancer: 10-year experience at a single institution
  publication-title: AJR Am J Roentgenol
  doi: 10.2214/AJR.11.7533
  contributor:
    fullname: Vinjamoori
– volume: 54
  start-page: 3078
  issue: 12
  year: 1984
  ident: 10.1016/S2311-3006(16)30027-1_bib6
  article-title: Metastatic patterns of prostatic cancer. Correlation between sites and number of organs involved
  publication-title: Cancer
  doi: 10.1002/1097-0142(19841215)54:12<3078::AID-CNCR2820541245>3.0.CO;2-U
  contributor:
    fullname: Saitoh
– volume: 128
  start-page: 331
  issue: 2
  year: 1982
  ident: 10.1016/S2311-3006(16)30027-1_bib8
  article-title: Mediastinal metastases from prostatic carcinoma
  publication-title: J Urol
  doi: 10.1016/S0022-5347(17)52913-4
  contributor:
    fullname: Lindell
– volume: 274
  start-page: 1214
  issue: 15
  year: 1995
  ident: 10.1016/S2311-3006(16)30027-1_bib3
  article-title: Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening
  publication-title: JAMA
  doi: 10.1001/jama.1995.03530150038031
  contributor:
    fullname: Catalona
– volume: 263
  start-page: 872
  issue: 9
  year: 2006
  ident: 10.1016/S2311-3006(16)30027-1_bib7
  article-title: Supraclavicular lymph node : incidence of unsuspected metastatic prostate cancer
  publication-title: Eur Arch Otorhinolaryngol
  doi: 10.1007/s00405-006-0066-2
  contributor:
    fullname: Hematpour
– volume: 31
  start-page: 578
  issue: 5
  year: 2000
  ident: 10.1016/S2311-3006(16)30027-1_bib9
  article-title: Metastatic patterns of prostate cancer: an autopsy study of 1.589 patients
  publication-title: Hum Pathol
  doi: 10.1053/hp.2000.6698
  contributor:
    fullname: Bubendorf
SSID ssj0001922474
Score 1.9219146
Snippet Abstract Prostate cancer typically metastasizes to bones and regional lymph nodes. Generalized lymphadenopathy is a rare manifestation of metastatic prostate...
Prostate cancer typically metastasizes to bones and regional lymph nodes. Generalized lymphadenopathy is a rare manifestation of metastatic prostate cancer. We...
SourceID doaj
crossref
elsevier
SourceType Open Website
Aggregation Database
Publisher
StartPage 70
SubjectTerms generalized lymphadenopathy
Hematology, Oncology and Palliative Medicine
malignant lymphoma
prostate cancer
Title Rare Presentation of Prostate Cancer Mimicking Malignant Lymphoma with Generalized Lymphadenopathy
URI https://www.clinicalkey.es/playcontent/1-s2.0-S2311300616300271
https://dx.doi.org/10.1016/S2311-3006(16)30027-1
https://doaj.org/article/2ef75f616afb41d6a394926f276b7c0c
Volume 1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV07T-QwELYQBaJBvE7sHSAXFFwRiB3HdkpAIATsicch0Vl-oj1pN2gXCvj1jO3ssjRcQxPJTiyPZjKez_Y8ENqrNK1i3ZCC1aBujJawDnLPCsa5dzXAOZ6uYvp_-Pk9u3ioH-ZKfUWfsJweODPukPog6sAJ18Ew4riumpjjLlDBjbClTatv2cxtpv5l3EJZSsEM-CUesJT8I3zn8G7WuU_47ypuzQryyTCl_P1z9mnO5pytopUOLOKjTOQaWvCjdbTU767DN5C51WOPrz8iiEa4DdBuU5gQPokSHeP-YDiw8UQc9wF0P0bPF3z1ClJshxrHc1jc5Z4evHmX32hYjdpYrPh1E92fnf49OS-6ogmFpaIkBdg8QbwmJgRSet6AeTZ1GcCuO-0aySqtpWOEGSmCdE3QuqLGgVpbZ6gHHf-BFkftyG8hLCzjTkvJpYBxtTSwlRbO29Boam3Ne-hgyjH1lHNjqJnTWGSxiixW0EosVqSHjiNfZx_H1NapAwSuOoGr_wm8h8RUKmoaPQrrnZ90yjdRRE2oKjMJkQLC0_wwvZyN7PBFxg1AxOBryn9-B-W_0DLALZYdzbbR4vP4xe8ApHk2u-nvhefljXwHzI_uFw
link.rule.ids 315,783,787,867,2109,27936,27937
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Rare+Presentation+of+Prostate+Cancer+Mimicking+Malignant+Lymphoma+with+Generalized+Lymphadenopathy&rft.jtitle=Journal+of+cancer+research+and+practice&rft.au=Tsai%2C+Yu-Fen&rft.au=Cho%2C+Shih-Feng&rft.au=Wu%2C+Chun-Chieh&rft.au=Liu%2C+Ta-Chih&rft.date=2014-06-01&rft.issn=2311-3006&rft.eissn=2311-3006&rft.volume=1&rft.issue=1&rft.spage=70&rft.epage=74&rft_id=info:doi/10.1016%2FS2311-3006%2816%2930027-1&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_S2311_3006_16_30027_1
thumbnail_m http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F23113006%2FS2311300616X60016%2Fcov150h.gif