Posttransplantation tuberculosis management in terms of immunosuppressant cost: a case report in Myanmar

• Published in: Korean Journal of Transplantation Vol. 35; no. 1; pp. 48 - 52
• Main Authors: Lwin, Phyo Wai, Htun, Yi Yi, Myint, Aung Kyaw, Swe, Htar Kyi
• Format: Journal Article
• Language: English
• Published: The Korean Society for Transplantation 31.03.2021; Korean Society for Transplantation; 대한이식학회
• Subjects: Case Report; post renal transplant tuberculosis; immunosuppressant cost; drug interaction; 의학일반
• ISSN: 2671-8790; 2671-8804
• DOI: 10.4285/kjt.20.0041

Drug interactions between anti-tuberculosis and immunosuppressive medications after renal transplantation are a common problem in Myanmar. The efficacy of both types of drugs can be reduced during the treatment period, which can lead to graft failure and flare-ups of infection. Drug adjustments, with frequent monitoring and close follow-up, are crucial in this period. Ketoconazole decreases tacrolimus metabolism by inhibiting cytochrome P450-3A5 enzymes and P-glycoprotein. It is cost effective and has been frequently used to reduce the dose and cost of tacrolimus. Here, we report the case of a 56-year-old male renal transplant recipient with anti-tuberculosis medications.