Structural Analysis Sheds Light on APC/C-Mediated Ubiquitylation

In the December 22nd issue of Molecular Cell, two groups report refined cryo-electron microscopic structures of the APC/C at ∼20 Å resolution. They also reveal important new features including multiple copies of subunits, dimerization and structural flexibility of the APC/C, which give a hint to sol...

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Bibliographic Details
Published inDevelopmental cell Vol. 10; no. 1; pp. 4 - 5
Main Authors Kimata, Yuu, Yamano, Hiroyuki
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 2006
Subjects
Anaphase-Promoting Complex-Cyclosome
Animals
Humans
Polyubiquitin - metabolism
Protein Structure, Quaternary
Ubiquitin-Protein Ligase Complexes - chemistry
Ubiquitin-Protein Ligase Complexes - genetics
Ubiquitin-Protein Ligase Complexes - metabolism
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Summary:In the December 22nd issue of Molecular Cell, two groups report refined cryo-electron microscopic structures of the APC/C at ∼20 Å resolution. They also reveal important new features including multiple copies of subunits, dimerization and structural flexibility of the APC/C, which give a hint to solve the mechanisms of the APC/C-dependent ubiquitylation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2005.12.010