Enhancement of photodynamic tumor therapy effectiveness by electroporation in vitro

• Published in: Medicina (Kaunas, Lithuania) Vol. 45; no. 5; pp. 372 - 377
• Main Authors: Labanauskiene, Jūrate, Satkauskas, Saulius, Kirveliene, Vida, Venslauskas, Mindaugas, Atkocius, Vydmantas, Didziapetriene, Janina
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2009
• Subjects: Animals; Cell Line, Tumor; Electrochemotherapy; Electroporation; Humans; Indoles; Microscopy, Fluorescence; Neoplasms - drug therapy; Organometallic Compounds; Photochemotherapy - methods; Porphyrins; Radiation-Sensitizing Agents

The aim of our study was to determine if electroporation could improve the efficacy of photodynamic tumor therapy. A disadvantage of photodynamic therapy is a slow and in some cases insufficient accumulation of photosensitizer in tumor tissue, which could restrict the achievement of an efficient dos...