Rational study design for prophylaxis of postoperative nausea and vomiting

To the editor： In the recent article of Fang and colleagues1 ssessing prophylactic efficacy of a single-dose of dexamethasone before anesthesia induction on postoperative nausea and vomiting （PONV） in patients undergoing microvascular decompression for facial spasm, they showed that dexamethasone di...

Full description

Saved in:
Bibliographic Details
Published inChinese medical journal Vol. 127; no. 19; p. 3520
Main Authors Li, Ruiping, Xue, Fushan, Cui, Xinlong, Wang, Shiyu
Format Journal Article
LanguageEnglish
Published China Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 2014
Subjects
Humans
Postoperative Nausea and Vomiting
Research Design
地塞米松
微血管
恶心呕吐
止吐
肌痉挛
设计
随机对照试验
预防效果
@@
Online AccessGet full text

Cover

More Information
Summary:To the editor： In the recent article of Fang and colleagues1 ssessing prophylactic efficacy of a single-dose of dexamethasone before anesthesia induction on postoperative nausea and vomiting （PONV） in patients undergoing microvascular decompression for facial spasm, they showed that dexamethasone did not prevent PONV. Actually, meta-analyses of double-blind randomized controlled trials comparing dexamethasone with controls indicate that this antiemetic is effective in the prophylaxis of postoperative vomiting and reduced use of rescue antiemetics.2 In our views, some limitations of this study design may have made interpretation of their conclusions questionable.
Bibliography:To the editor： In the recent article of Fang and colleagues1 ssessing prophylactic efficacy of a single-dose of dexamethasone before anesthesia induction on postoperative nausea and vomiting （PONV） in patients undergoing microvascular decompression for facial spasm, they showed that dexamethasone did not prevent PONV. Actually, meta-analyses of double-blind randomized controlled trials comparing dexamethasone with controls indicate that this antiemetic is effective in the prophylaxis of postoperative vomiting and reduced use of rescue antiemetics.2 In our views, some limitations of this study design may have made interpretation of their conclusions questionable.
11-2154/R
SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.20141738