The synthesis of a novel carbazole-linked cyclic peptoid with antibacterial activity

This paper describes the synthesis of a novel cyclic peptoid 11, structurally comprising a tripeptide moiety linked through a carbazole scaffold. In a key step, a ring-closing metathesis reaction was used giving efficient access to a new class of cyclic peptoids.

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Bibliographic Details
Published inSynlett no. 2; pp. 219 - 222
Main Authors Bremner, JB, Coates, JA, Keller, PA, Pyne, SG, Witchard, HM
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.02.2002
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
antibacterial activity
INFECTIONS
VANCOMYCIN
cyclic peptoid
EMERGENCE
ring-closing metathesis
METATHESIS
RESISTANT ENTEROCOCCUS-FAECIUM
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Summary:This paper describes the synthesis of a novel cyclic peptoid 11, structurally comprising a tripeptide moiety linked through a carbazole scaffold. In a key step, a ring-closing metathesis reaction was used giving efficient access to a new class of cyclic peptoids.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2002-19754