Computed Tomography Scanning in Cystic Fibrosis Research Trials: Practical Lessons from Three Clinical Trials in the United States

• Published in: Proceedings of the American Thoracic Society Vol. 4; no. 4; pp. 350 - 354
• Main Author: Brody, A. S.
• Format: Journal Article
• Language: English
• Published: United States 01.08.2007
• Subjects: Adolescent; Adult; Child; Clinical Trials as Topic; Cystic Fibrosis - diagnosis; Cystic Fibrosis - diagnostic imaging; Gene Transfer Techniques; Humans; Middle Aged; Outcome Assessment (Health Care); Purinergic P2 Receptor Agonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y2; Respiratory Function Tests; Tomography, X-Ray Computed

Over the last 15 years, several clinical trials in subjects with cystic fibrosis (CF) have employed computed tomography (CT) scanning as an outcome surrogate. These research trials have increased our knowledge about the appearance of the lungs in patients with CF, and the relationship between the CT...